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Inhibition of eukaryotic DNA polymerases alpha and beta by anthracycline analogues.
The inhibition of the three eukaryotic DNA polymerases, alpha, beta and gamma has been examined using the in vitro assay system. It was found that the polymerases were inhibited by drugs with a wide variety of mechanisms of action. The specific inhibition of alpha was readily distinguished from the non-specific inhibition of other polymerases by three different characteristics. The two main mechanisms 50e0806aeb whakal
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